Gonzales v. Raich

Patients and petitioners grew and consumed marijuana for medicinal purposes. Although their consumption was authorized under a California statute, the federal government, under the CSA, confiscated the drugs. The respondents claimed that enforcing the CSA against them would violate the Commerce Clause, the Due process clause of the 5th amendment, and the ninth and tenth amendments of the U.S. Constitution.

Congress can regulate commodities that in the aggregate may have a substantial effect on interstate commerce.

Powers of Congress | Commerce Clause